Shared and Distinct Defects in ASD and Schizophrenia found in mice

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An article published in the Neuron Journal about Mice with Shank3 Mutations Associated with ASD and Schizophrenia Display Both Shared and Distinct Defects highlighting (1) Major psychiatric disorders share many risk genes; (2) Two mouse lines with ASD-linked and schizophrenia-linked mutations were studied; (3) Two mutant lines show both shared and distinct synaptic and behavioral phenotypes, and (4) Both developmental and molecular differences were detected in the two mutant lines