Inhibiting Inflammation Improves AD Cognition

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• AD stands for 'Alzheimer's Disease'
  • A progressive, degenerative disorder
• Abeta stands for 'Beta-Amyloid'
• Study, demonstrated key role of inflammation in AD memory loss
• Researchers used a molecule inhibitor, PLX3397 (used in treatingjoint benign neoplasm), to:
  • Selectively block microglial surface receptors signals, this in turn:
    • Reduced inflammatory cells
• In mice treated with PLX3397 inhibitor, scientists, saw:
  • Improved memory and cognition
  • Absence of neuron death
  • Dendritic spines growth
• More research into abeta, inflammation, neurodegeneration; linkage
• Published in the journal Brain