Highlighting the Neuroprotective Potential of SKIP Therapy

Photo: NICHD / flickr/ cc by

• AD stands for 'Alzheimer's Disease'
  • A progressive, degenerative disorder
• ADNP stands for 'Activity-dependent neuroprotective protein' and is frequently mutated in:
  • Children with autism spectrum, and
  • Older adults who have AD
• SKIP stands for, 'four-amino-acid peptide ADNP-replacement therapy'
• New research highlights the neuroprotective potential of SKIP therapy which when administered:
  • Accelerated microtubular function
  • Increased, repaired and normalized blocked nerve-cell transport
  • Behaved like the ADNP-intact mice
• Findings also suggest, that in male mice are much slower in the movement of transported material through nerve cells
• Significance:
  • Therapeutics can be optimized to treat both autism and AD
  • Clinicians should consider gender-significance when treating
• Published in Molecular Psychiatry