Faulty Signaling Pathway, New Rett Syndrome Drug Target

Credit: bburt33/Foter

• Rett syndrome (RTT), a neurological and developmental disorder
• Researchers identified IRAK1 gene in NF-kB signaling pathway producing 3 times more protein in RTT cases
• When researchers reduced IRAK1 protein development by half:
  • Neurons/dendrites developed better
  • Fewer RTT symptoms
  • Better function
  • Longer lifespan
• Application: could lead to future compounds/drugs to help RTT cases
• Published in the Journal Nature Communications